Interleukin-4 and interleukin-13 induce fibronectin production by human lung fibroblasts
نویسندگان
چکیده
منابع مشابه
Protection of human conjunctival fibroblasts from NO-induced apoptosis by interleukin-4 or interleukin-13.
PURPOSE To examine the possible roles of T helper type 2 (Th2) cell-derived cytokines in formation of the giant papillae characteristic in individuals with vernal keratoconjunctivitis, the effects of these cytokines on the proliferation and apoptosis of cultured human conjunctival fibroblasts were investigated. METHODS Apoptosis was induced by the NO donor sodium nitroprusside. Cell viability...
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Airway hyperresponsiveness leading to subepithelial fibrosis is mediated by inflammatory cells activated by T helper (Th) 2-derived cytokines such as IL-4 and IL-5. By analyzing the phenotype and response of human lung fibroblasts derived from either fetal (ICIG7) or adult (CCL202) tissue as well as from a Th2-type stromal reaction (FPA) to IL-4 and IL-13, we provide evidence that human lung fi...
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Interleukin (IL)-4, IL-10, and IL-13, Th2 cell-derived cytokines, play major roles in the pathophysiology of allergic diseases. These cytokines up-regulate or down-regulate the production of arachidonic acid metabolites. In this study, we have investigated the effect of IL-4, IL-10, IL-13, and other cytokines on A23187-stimulated synthesis of leukotriene (LT) B(4) in human polymorphonuclear leu...
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ژورنال
عنوان ژورنال: Allergology International
سال: 2001
ISSN: 1323-8930
DOI: 10.1046/j.1440-1592.2001.00220.x